Accepted answer: no
My first time through Dishonored, I'm playing the way I played Deus Ex - silent and compassionate. I've got a couple runes and I've just met Granny Rags, so I'm not very far into the game at all. I'm trying to figure out where best to allocate my points to enable a sneaky playstyle.
Things like Shadow Kill and Bloodthirsty are useless to me, because if I'm playing properly, I should never be killing anyone. I know that in most Deus Ex-likes, there's a heavily-guarded path that requires nothing but murder to get through, and a lightly-guarded path that requires certain abilities to get through. This is the path I plan to take through the game.
Reading the descriptions of the various powers, it seems that Agility would be helpful for the greater jump height, but Possession would be helpful to crawl through small spaces as a rat...but I don't know how many small places there will be versus how many high places. Also, Possession II would allow me to walk enemies into lonely areas so that I could dispatch them more easily...but I don't know if I'm going to have enough runes and mana to make that strategy viable anytime soon.
In the early game, which is more useful to a stealth-based character, the extra jump height granted by Agility or the ability to travel through small spaces and relocate enemies granted by Possession?
